Effects on the brain from long term Percocet use (INFOGRAPHIC)

When exposed to Percocet on the long term, our brain goes through several changes in its function and structure. This infographic helps you explore Percocet’s long term effects on the brain.

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Percocet effects

Oxycodone, the main ingredient in Percocet, is a central nervous system (CNS) depressant. As the main ingredient, it gives Percocet the ability to provide pain relief by acting on µ and kappa opioid receptors in the spinal cord, brain, and other tissues.

Brain effects from long term Percocet

Percocet abuse has a strong potential to cause short and long-term psychological effects. It’s an opioid painkiller (or narcotic) and can cause euphoric sensation within the brain just like other opiates including heroin and morphine. When exposed to Percocet for a long period of time, the brain goes through a number of functional and structural changes. These side effects include:

Effects on the brain from long term Percocet use (INFOGRAPHIC)

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  • addiction
  • anxiety
  • confusion
  • cravings
  • dimness in vision
  • headaches
  • memory problems
  • mood swings
  • nervousness
  • paranoia
  • shallow respiration

All these effects on the brain can have a negative effect on:

  1. Your general physical health and well being.
  2. Your interpersonal relationships.
  3. Your financial state and savings.
  4. Your way of life.

Long term Percocet use and the brain questions

Explore our infographic to learn more in a fun and easy-to-understand manner. Feel free to share it if you find it contains useful information that may help others.

Got more questions about what continuous and chronic use/abuse of Percocet can do to your brain, psychological state, behavior, mood, and nervous system? Please leave them in the comments section below.


About the author
Lee Weber is a published author, medical writer, and woman in long-term recovery from addiction. Her latest book, The Definitive Guide to Addiction Interventions is set to reach university bookstores in early 2019.


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  1. If been dependant addicted to Percocet for over 10 years. I’ve recently started a slow taper,but have become paranoid with anxiety. Will this eventually get better or is it permanent? And what kind of options do I have?

  2. I am having vision problems – cataracts in both eyes but not percentage enough for insurance to cover surgery – but now in ONLY my left eye I notice that horizontal and vertical lines have waves in them – actually what I would call camel bumps more than wavey lines – and would like to know if percocet could contribute to this eye problem. I am one three a day 7,5/3,25 mg and have been for about a year due to Piriformis Syndrome. I tend to doubt percocet being the problem since it is only my left eye that “sees” those constant ‘bumps’ — please respond. Thank you, Linda

    1. Hi Linda. Percocet is used for treating pain. I suggest that you consult with an optometrist and/or ophthalmologist about your vision problems.

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