Tuesday February 20th 2018

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Long term effects of morphine on the brain (INFOGRAPHIC)

Morphine directly targets the central nervous system and changes the way in which the body feels and responds to pain. More precisely, it binds to opiate receptors in the brain and changes the neurochemical activity in the brain stem which can result in alteration of the automatic body functions. It also affects regions in the brain responsible for pleasure and with regular use the brain starts to register the effects of the morphine as a reward. Explore this infographic further for more details.

Specific long term effects of morphine on the brain

Morphine effects on the nervous system

  • depressed consciousness
  • diminished reflexes
  • general psychomotor impairment
  • possibility for seizures
  • slowed reaction time

Morphine effects on neurotransmitters

  • affects m-receptors, and also at k- and d-receptors
  • binds to opiate receptors within the reward pathway
  • binds to receptors concentrated in areas of the pain pathway
  • causes sedation, relaxation and drowsiness
  • gives short-term feelings of emotional well-being, warmth and pleasure
  • major effects on the Central Nervous System (CNS)
  • produces euphoria and elevated mood

The effects of morphine on personality

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  • alterations in personality
  • compulsion to use morphine
  • inattentiveness
  • neglecting formerly enjoyable activities and hobbies
  • obsessive behavior over obtaining morphine

How morphine affects behavior

  • apathy
  • destructibility
  • euphoric behavior
  • lethargy
  • sudden mood and action changes

The psychological effects of morphine

  • abnormal thoughts
  • delirium
  • disconnectedness
  • disturbed sleeping
  • mental clouding
  • severe depression

What are typical morphine doses?

Abuse typical doses

Per day recreationally …… 30-60 mg orally as a starting dose

Addicts can administer 1 to 3 times per day.

Addicts with high tolerance to morphine can use 2000-3000 mg daily.

Lethal typical doses

Overdose ………… 200mg is the least amount needed for overdose. But, in case of over sensitivity to morphine, 60mg can be fatal.

How long is “long term”?

For short-term relief of severe acute pain morphine is used for about 4 weeks or 1 month. Long-term use is recommended for the management of chronic pain. However, morphine should never be taken longer than 12 years.

Chronic use of morphine = repetitive and pattern-followed morphine abuse that reflects negative consequences on:

  • person’s economic stability
  • social relationships
  • state of health
Long term effects of morphine on the brain (INFOGRAPHIC)

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11 Responses to “Long term effects of morphine on the brain (INFOGRAPHIC)
5:09 am November 26th, 2016

I have been on these drugs for many,many yrs.I am now whining off all of them.Although I have done this before,on my own,I would never suggest,that anybody do that.I am now working with a professional team,to help me do that safely.It consists of my family doctor,a senior nurse,(which is trained in that field)plus a pharmacist.They are great,understanding,patient,wonderful,and I am grateful every day for there help.I would love to speak,about what it has caused in my life.Everything was in shambles.My health,family,friends,my mind(in many ways)& the list goes on.I had been asking my doctors,to get off these horrid meds,to hear,hoe r u going to control my chronic pain.In one month,I have regained my memory,balance,depression state is much better,constipation,confusion,psychotic behaviour,not caring about important things,not able to carry a conversation, lost my self esteem,balance,sleeping deprevation,although I was insomiac for yrs,things got much worse.Lucky to get8 to 10 hrs,in as many days as 5,& that happens very often.I am totally exausted most of the time,with reason.my sleep specialist could not understand why I was still alive,after all these yrs,without any decent sleep.I ask myself that same question????? Well the important point,is that I have turned it around&doing very well.Everybody is impressed wih my progress.I am not naive enough to think this is over,but relieved that it is the beginning of a whole new life,.one of quality,and one I am so much looking forward to.So far,the withdrawals have been really acceptable.I am on the road to wellness.I could say much more,but I would have to write a long book.If ever I can help someone,I would jump at opportunatly Good luck to everyone going through this bad scene.Hope this will be of help..

Lydia @ Addiction Blog
2:32 pm December 9th, 2016

Thanks for sharing, Diane.

6:53 pm April 25th, 2017

Just in case you don’t realize why you’re not getting comments on your blog, I was just accused of being spammy after writing about my experience with a user. Thanks you need to adjust your filters. Just because I know how to spell( and use spell check) doesn’t make me spam! Notice you only have 1 comment.

Lydia @ Addiction Blog
2:08 pm April 27th, 2017

Hi Lisa. Sorry for your troubles. Right now we’re working on new software, and some of the comments are marked as spam. However, you may send us the article’s link and your comment at info@addictionblog.org , and we’re going to post it manually.

4:05 pm May 4th, 2017

My husband is an amputee and has all kind of back problems. He sees a pain management Doctor once a month to get his morphrine. He takes morphrine IR 15mg twice a day and morphrine ER 100mg twice a day. He is usually a easy going man but about once or twice a week he gets ANGRY or mad over the smallest thing and then we have a huge blow up. He has been taking this for about 6 years and since his amputation about 20 years ago has been on just about every pain med.

My question, is taking morphrine can it make you angry? He is also VERY forgetful but my main question can taking morphrine change your personality and make him mean? Thank you, Joan

Lydia @ Addiction Blog
2:00 pm May 22nd, 2017

Hi Joan. Morphine may have an impact person’s behavior. I suggest that you speak with your husband’s doctor about his behavior, and you may consider family counseling. Keep in mind that your husband has gone through very serious life situation, so maybe he needs counseling sessions on his own.

11:34 pm May 30th, 2017

Morphine can cause a change in the personality of a person because it can cause a person to become agitated as a possible side effect, and causes memory loss due to morphine blocking the brain’s ability to strengthen at inhibitory synapses which is a key process the brain needs to store information.

5:19 am June 18th, 2017

Having read this, I can confirm that Morphine affects previously enjoyable activities, which for me was exercising.
Over a decade ago my leg was smashed to pieces in a traffic accident, to put my leg back together they dosed me up with Morphine, and I think they gave me too much because I was out of it pretty hard, my mind went to a places it has never been before and thankfully never again, but then my leg got pin and it took me about a year to fully heal.
However, went I tried to enjoy exercising, something had changed, it was no longer an enjoyable activity, all exercise became was tiring and exhausting with no emotional compensation, something that had to be done then became something that could be skipped because I wanted to conserve energy for things that mattered more.
I honestly do not know if Morphine was the cause, but I can not think of anything else that may have affected my mind in such a manner, it has been over ten years and nothing has changed, physical effort is still no longer enjoyable and something that I will avoid if at all possible, any motivation to get fit or develop muscles is non existent, thankfully being a slim guy means I can hide my problem in plain sight.
Thank you for the article.

8:14 pm July 6th, 2017

11 years ago I was in a terrible car accident which left me with severed & damaged nerves in the wrist and hand. 13 surgeries later & I was referred to a pain specialist. Fast forward 11 years-daily Im prescribed 90mg Ms Contin ER, 120mg Oxycontin, 6 pills daily Percocet 10-325 & 600 Lyrica for pain. Honestly, I rarely leave comments. I figure my story isnt much different. But this is for the person who like me, couldn’t understand the total change in my personality and couldn’t figure why I felt so dead inside! Or for the family who can’t understand who their loved one has become and trying to find some way not to take it all personally. My Dr NEVER told me that these where typical long term use effects. Even when I mentioned them. Before pills, I was physically active. I was responsible, hard-working, creative, organized and motivated. Lots of friends, hobbies, 10yrs of good marriage etc. Not perfect but living my own life. NOW? I sit in my Shrinks office, anti depression scripts in hand, crying, begging, please FIX ME! Why can I not seem to get motivated and interested in living anymore? I was told I was bipolar & (my minor went major) suffering PTSD from accident/trauma & maybe this dosage/type I will feel better in few wks. I had now isolated myself to where I lost most of my friends, people we’re constantly commenting on my anger and irritability. My husband and I haven’t slept in the same bed together for almost 8 years & we will be getting a divorce soon. My house shades rarely open. I can’t throw papers, mags, etc away. I stopped taking care of myself… gained 40lbs & hate looking in mirror so I avoid leaving the house. …….. I’m just starting my journey to get to the other side. To find my way back from addiction and learn new ways to live with my chronic pain instead of just existing with pills. These drugs affect your brain. Scientific proven fact. I’m reaching down into the rabbit hole to help pull you up. Here, where ”true you” will be waiting… you can see that taking opiads destroys one of the most precious things you will ever own ….your health and your spirit. God bless you and good luck.

2:38 pm September 3rd, 2017

I am 70 years old with severe degenerative disc disease and facet arthrosis. Had to quit working due to pain 15 years ago. Tried every alternative to opiates, i.e. injections, PT, anti-inflammatories, muscle relaxers, etc. Allergic to all opiates except morphine. Was on 30 mg morphine sulfate ER BID for about 2 years then weaned off and pain returned. Have been on 15 mg morphine sulfate ER QD for a year. Never had cravings or any noticeable side effects even with withdrawal. However, worried about long term effects on life expectancy, etc. so weaning again. Pain is back and unable to do much of anything. Two questions: This time withdrawal has been bad mainly general body aching, malaise and chills still continuing after two weeks. Doctor says normal. Clonidine not helping. Is it normal for these symptoms to continue this long? Second question: Is there real evidence that using morphine responsibly shortens life or causes irreversible disease? Have read all the info on effects of morphine on the body and have never had any sign of any of them. The doctor will put me back on morphine if I want but I am leery and might live longer than the 12 year limit on morphine use.

8:08 am November 18th, 2017

My son was on morphine for months on end due to surgery and cancer. He hallucinates mostly about God but I am wondering if this is a mental condition or the effects of morphine. Please help.

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