Methadone affects the whole organism
The major adverse effect of methadone is respiratory depression and other most commonly observed side effects include lightheadedness, dizziness, sedation, nausea, vomiting and sweating. But, methadone also affects how the brain functions, thus changes the way people behave and feel.
Adverse methadone effects on health and life
Through habitual and progressive use, methadone takes a toll on the physical, mental and emotional health, including relationships.

Behavioral effects:
- loss of enjoyment for the simple things in life
- indifference towards family, friends and loved ones
- loss of interest in once enjoyable activities
- diminished ambitions and professional drive
Physical effects:
- loss of appetite
- loss of restful sleep and sleep disturbances
- impaired libido
- menstrual cycle changes
- difficulty in breathing
- skin turning cold or clammy
- urinary retention
- constipation
- extremely dry mouth
- headaches
- blurred vision
- liver toxicity
Psychological effects:
- irritability
- anger
- self-criticism
- feelings of sadness and emptiness
- depressions
- mood alterations or mood swings
- confusion
- restlessness
- nervousness
Serious adverse effects and questions
In the case of overdose, emergency medical help should be sought immediately. If people who’ve OD-d are left untreated they can fall in coma, and experience hallucinations that can lead to self harm or physical harming of other people. In the worst case scenario, death is also possible. Please comment below and share your thoughts or questions, and we’ll try to respond personally and promptly.
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