Negative consequences of oxycodone (INFOGRAPHIC)

Long-term use or illicit abuse of oxycodone can impact your psychological and physiological well-being. Some negative effects include dependency, feeling high, occurrence or worsening of anxiety and/or depression. Learn about the unwanted consequences of Oxy in our detailed infographic, here.

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Oxycodone side-effects

Using oxycodone chronically for a longer period of time can have many different side-effects. Although it can be helpful for people who are suffering from chronic pain, long-term use or illicit abuse can impact your psychological and physiological well-being.

Some negative consequences include dependency, feeling high, occurrence or worsening of anxiety or depression, etc. What other risks and dangers of oxy? Check out the infographic above to learn more, then post your questions or feedback in the section at the end of the page.

Negative consequences of oxycodone (INFOGRAPHIC)

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Mental and psychological effects

Oxy has the same effects on the brain and central nervous system (CNS) like other opioid narcotics, such as heroin or morphine. That’s why oxycodone got the name “hillbilly cocaine”. So, similarly to other opioids, this medication can have the following effects:

  • addiction
  • confusion
  • constipation
  • dizziness
  • liver damage
  • kidney damage
  • nausea
  • vomiting

Serious physical damages

  • coma
  • death
  • kidney and liver failure
  • respiratory depression
  • risk of heart attack
  • severe liver damage

Sex and fertility risks

Oxycodone has the ability to cause changes in human hormonal levels and throw them off balance, resulting in:

  • cessation of menstrual periods
  • decreased libido
  • difficulty having/keeping an erection
  • disturbed menstrual cycle
  • testosterone depletion
  • lowered sperm count

In addition, oxycodone abuse may lead to someone having risky sexual encounters, and getting STDs, Hepatitis B or C, HIV/AIDS.

Adverse oxycodone effects questions

Like our infographic? Feel free to share it with your connections and spread the awareness about the negative effects from abusing opioid painkillers. For any further questions, please post them in the comments section below and we’ll get back with you personally and promptly.

About the author
Lee Weber is a published author, medical writer, and woman in long-term recovery from addiction. Her latest book, The Definitive Guide to Addiction Interventions is set to reach university bookstores in early 2019.


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  1. I am taking 30 mg of oxy and have Elers Danlos Syndrome. My joints are deteriorating and I have had 15 surgeries. I really want to come off these pain pills but I fear I won’t be able to live a productive life without some sort of pain management. I feel like doctors don’t help to find other ways to help but pills.

    1. Hi Roxy30. Have you tried consulting another doctor? Medline Plus provides links to directories to help you find health professionals. Here is the link:
      Here are some suggestions on how to relieve joint pain naturaly:
      -rest your painful area and try a hot-and-cold approach to manage the pain. You can use therapeutic gel to the affected area for several minutes.
      -try peppermint essential oil and/or eucalyptus oil to inflamed spots.
      -try getting as much movement as you possible can.
      eat food rich in antioxidants.
      Hope this helps.

  2. I agree with pain survivor. I am prescribed oxycodone 20 mg. I ask my doctor to give me a pain medication that did not contain Tylenol due to the fact it effects the liver. I was a all around athlete until age 51. My mother and father had osteoarthritis and so do I. The cartilage protecting my joints are pretty much gone. I’ve had surgery on a torn meniscus in my left knee also surgery on my right shoulder in which a quarter of my clavical was removed. I am the original T-Pain due to the pain I go through with my joints. I was told I eventually need to get my knees hips and shoulders replaced. My pain medication do not take all the pain away it just makes it bearable. I hope I can hold on until technology comes up with a way to help me with my condition due to the fact replacing my joints with something artificial don’t sound good to me. Plus I have allergic reactions to metal. I am one of those individuals who need and don’t abuse their pain medication so please figure out a way to decipher who is who in the pain business. Pain kills also.

  3. I have donated a kidney and have close monitoring of my kidney. This medication when taken as prescribed is not harmful. Nsaids are more harmful then this. I have never have had violent behavior. This medication has gotten a bad rap because of those who abuse it! Let me point out if they abuse this chances are they’d abuse almost anything. I don’t steal, I don’t lie. This is ridiculous. I am in pain management due to several issues one being spinal stenosis. But others are in way worse shape and because we have a little relief from pain we are able to lead a somewhat close to normal life. I’m thankful it’s available. People are being brainwashed it’s a horrible drug that’ll destroy your life. Have personal responsibility for the things that you do and if you are abusing drugs or know someone that does its a flaw with will power to begin with. I have stopped the drug on my own with out spiraling out of control etc. To years later when my condition worsen we decided to go with a low dose . Never have ran out ,never have I taken more than prescribed. Senseless lies. Please don’t just follow the hype and jump on the bandwagon and labeling this a bad drug it’s bad people with bad habits that gives it a bad name. I’d like to add a couple of things . I have been married for over a decade and libido is not an issue. We are very active and love each day like newlyweds. I had a tubal reversal and had a beautiful baby girl, about the only true thing to this article is this difficulty using the restroom but they have stool softer if it’s a huge problem. I wish someone would poll me when they are gathering information. It’s biased ,and unfactual, I seriously doubt I’m the only one that can debunk the majority of these lies. It’s just sad. This is the Marijuana will make you jump out of the window hysteria all over again. And no I do not use Marijuana I don’t like smoke nor do I like the effects but I’m not bashing it either.

  4. I’m so ready to stop this Pain Medicine “Roxy30mg” .I’ve been prescribed this since 2004. I know it’s going to be hard to stop, but I want to so bad, I can’t stand it anymore. It controls me, and I’m ready to Live my life again before I was ever given this Drug . I know Life won’t be the same as once was ever again. However, I’ve got too many people in my life i love & I need to be at my best. Please Pray for me because I need it. Please Help with any advice on Quitting. I don’t want to replace one drug with another as in Methadone & Suboxone. I’ve thought of weining off with my Xanax, Try to sleep, eat lightly, drink fluids & One Minute at a time. I’m crying as I’m writing this because nobody knows how much I wished I could say, I’m Clean from Roxy & I Pray I can do this. It’s the Holidays & I need to think about my Kids, Grandkids, Mom, And Husband. I know I won’t get to go to Bed & try to get thru it that way, so I’m going to start and Clean Myself Up.
    Any help will be greatly appreciated. Congrats to You All who got Clean, There should be a Holiday to Celebrate Sobriety.

    1. Hi Red Doll 55. I suggest that you consult with your doctor to help you plan an individualized tapering schedule. Also, talk with a pharmacist to recommend some over-the-counter aid, home remedies, teas, supplements and vitamins to help you ease withdrawal symptoms.

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