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How long does Demerol stay in your system?

How do you take Demerol?

Demerol (the brand name for the medicine called meperidine) is most often taken as needed. Demerol is usually either injected into a large muscle or added to an IV drip by a doctor. However, you can also take Demerol orally as a tablet or a liquid syrup every 3-4 hours as needed and prescribed.  What is Demerol used for?

People who become dependent on Demerol or who use the medication for non medical reasons may crush, chew, snort, or inject the drug. Less common modes of administration include rectal administration or blowing Demerol powder into the lungs. These ways of taking Demerol are major signs of possible prescription pill addiction to Demerol.

Half life: How long does Demerol stay in your system?

When we talk about drugs in the body, most health professionals refer to a drugs “half life”. A half life is the amount of time it takes for half of the drug to be removed from a person’s bloodstream. Demerol is a narcotic with a half-life of 2.5-4 hours in adults. This means that it takes 2.5 – 5 hours for one-half the dose of Demerol to leave the body after it has been administered (either by injection, tablet or syrup). Elimination half-life affects the length of time the effects of Demerol are active and can be influenced by:

  • absorption rate
  • age
  • changes in urinary pH
  • diet
  • other medications
  • physical condition
  • pregnancy
  • protein binding
  • use of vitamins and herbal products
  • variable metabolism

Drug testing for Demerol

In general, it will take longer than 5 hours for Demerol to leave your body. If you’re worried about Demerol detection in your urine for drug testing, don’t.  Demerol does not usually show up on standard urine tests for opiates. This is because Demerol is an opioid analgesic medication and contains synthetic opiates, which do not metabolize to codeine, morphine, or 6-acetylmorphine.  Therefore, Demerol (meperidine) is not usually detected in urine.

Are you addicted to Demerol?

Given its acute medical uses and strong pain relieving effect, Demerol can be very addictive. This is why is it listed as a Class II drug by the DEA. To evaluate possible Demerol addiction, see the signs of Demerol use and withdrawal symptoms for opioid pain killers.  Or leave us your comments and questions. We respond to every comment in a comment or video!

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7 Responses to “How long does Demerol stay in your system?
6:05 pm January 15th, 2012

I would just like to point out a mistake on here. Demerol (Pethidine) Will never show in a standard urine test. You can take it and have a test 3 hours later and it will come back negative! Just thought I would let you know

1:21 pm January 16th, 2012

Thanks for sharing your experiences, INFO.

From my reading, I see that Meperidine Hydrochloride (Demerol) is one of the most commonly known opioid analogs. Analogs are chemical compounds that are similar to other drugs (in this case, opioids) in effects but differ slightly in chemical structure. So because synthetic or semi-synthetic narcotics do not metabolize to codeine, morphine, or 6-acetylmorphine they are not usually detected in urine. Thanks for the correction.

6:22 pm August 20th, 2013

I tke methadone now for 16yrs for severe pain but it stops working i feel as far as nerve pain in my back so i was so distressed that a friend gave me a quarter of a 50mg. meperitab which is Demerol it scared me at first cause i felt it within 10 min. then my was gone ! its been yrs since ive felt no pain at all! I slept as well till morning I will tell my doctor about it hopefuly he will understand .

6:29 pm August 20th, 2013

let me get this straight demerol (meperitab50mg) will not show in a urine screen . I find that hard to believe it has to come up something ! what if a person has one kidney?

9:04 pm December 27th, 2015

I am a former US Marine and I know that it will depend on what they are testing. No matter the branch the testing is done the same for all military members. I will give you this list for each duration and the duration for when the results will return:
THC- 1 to 3 weeks
Coke- 2 to 4 days
Amphetamines- 2 days
Barbiturates- 1 to 2 days
Op- 1 to 2 days
PCP- 5 to 7 days
L.S.D- 1 to 2 days
Steroids- 3 days or longer

Lydia @ Addiction Blog
7:06 pm December 28th, 2015

Thanks for sharing, Alex.

7:10 pm April 6th, 2016

Demerol will show up in your system I had a hysterectomy February 23rd and I went to visit my family doctor February 26th they did a urine test for my yearly screening and it showed up it was no biggie because I could explain it but still it was in my urine

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