Can you die from taking hydrocodone?

Yes, you can die from a taking hydrocodone during overdose. But in normal amounts, hydrocodone is usually safe. Symptoms and treatments for hydrocodone overdose here.

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Yes. Taking too much hydrocodone can kill you.

More on the risks and dangers associated with taking hydrocodone narcotics below. And we invite your questions and feedback about hydrocodone use at the end.

Systems affected by hydrocodone

Hydrocodone is a central nervous system depressant and an antitussive medication. Hydrocodone affects the brain causing drowsiness.  Hydrocodone can also affect the lungs.

Dangers of hydrocodone ingredients

Like all opiates, hydrocodone is addictive and can create compulsive drug-seeking behavior in users. It is also easy to develop a physical tolerance to the medication (which is different than addicytion), which require higher or more frequent doses of hydrocodone for same effect. Physical dependence is also indicated when you experience withdrawal symptoms during dose reduction or elimination.

Some of the serious side effects caused by hydrocodone are equally concerning. Hydrocodone in large amounts can slow breathing to the point where users lose consciousness or die. When combined with acetaminophen, hydrocodone overdose can cause severe liver damage.

Hydrocodone combined with other drugs

Hydrocodone is an opiate painkiller found in many different pain medications, usually in conjunction with acetaminophen (for example, Vicodin). Hydrocodone is also combined with aspirin or antihistamines, and is sometimes used in prescription cough medications. Because hydrocodone is only legally available combined with other drugs, the risk of overdose is compounded because often, the other drugs come with significant dangers of large doses.

Serious adverse side effects of hydrocodone

In moderate amounts, hydrocodone can cause dizziness, nausea, and related side effects. In high doses, hydrocodone can make breathing difficult. Withdrawals from the medication can make a hydrocodone dependent person seriously ill – causing insomnia, pain, and gastrointestinal issues. How long hydrocodone withdrawal take?  Ususally symptoms peak 2-3 days after last dose, although some hydrocodone withdrawal cases can last for days to weeks after this.

Signs of hydrocodone overdose

There are a few telltale signs of a hydrocodone overdose. These include three main symptoms:

  • breathing problems
  • extreme sleepiness
  • small (“pinpoint”) pupils

How to treat hydrocodone overdose

If you suspect you’ve taken too much hydrocodone, consult a poison control center or go to a hospital right away. If someone near you has overdosed on hydrocodone, seek professional medical help immediately or call 911. In some cases, all that’s needed is to monitor the person’s breathing until the medication wears off. Sometimes, however, oxygen or an antidote to the opiate will need to be administered. Prompt medical attention is very important, as a lack of oxygen can cause permanent brain damage.

Are you taking too much hydrocodone?

There are many reasons why someone might take high levels of hydrocodone. They may suffer from chronic pain and find that their prescribed dose does not help with symptoms. They may be abusing it to experience a “high.” If you’re a patient with a hydrocodone prescription and you find you’re having to take large doses for pain relief, speak to your doctor about adjusting your dosage or trying a different medication, so that you can avoid the risk of accidental overdose on hydrocodone or any of the other drugs in your medication.

And if think that you’re addicted to narcotics, there are support groups and medical treatments available to help. Please leave us your questions about taking hydrocodone, and its abuse here. We are happy to respond to all questions with a personal and prompt reply.


Reference Sources: Drug Enforcement Administration: Hydrocodone
PubMed Health: Hydrocodone
Medline Plus: Hydrocodone and acetaminophen overdose
About the author
Lee Weber is a published author, medical writer, and woman in long-term recovery from addiction. Her latest book, The Definitive Guide to Addiction Interventions is set to reach university bookstores in early 2019.


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  1. Well now with the new rules they have now in 2018, I was on percocet 10mg. When fell from a roof top, Got busted up pretty well in 2002, Then with more surgerys, And then loratab 7.5mg. And in 2005 I was put on tramadol till now, It help the withdrawal more than the pain, But now because of a Epidemic lol. My dr. Is so scared he talked about wanting to take me off them, I was 43 and never took opioids until I was hurt, And yes of coucourse I have a physical dependence now, And now doing with alot just because people taking to many, But my question is will we that need it just to function because of pain be cut off?

  2. I’ve got a chronic terminal autoimmune disease. I’ve been on Marco for 9 yrs. I want to stop but can’t handle the withdrawals. I haven’t been able to taper. if rather get it over with by going cold turkey but need some other medication to sleep through the hardest days. my docs don’t like the idea of cold turkey but I feel like that’s my only option. I’m a 60 yr old, used to be very active woman. that was all completely taken away from me 10 yrs ago. I’d rather od and die than going on like this, amid many other problems on the home front. I just can’t do it anymore nor do I want to. please advice

  3. My remarried ex husband took 25 hydrocodone pills 23 hours ago as a suicide attempt. How did he not die? Isn’t that a lot of pills?

  4. I take 4 hydrocodones 4times a day and they are no longer are helping my pain stop .when I first started I could take One 5 mg ,and it would last all I’m taking 4 75mg and it seems for nothing,I guess IV got immune to them.i tried to get pain management to increase for dosage to 10mg,by they would do it. Supposed to been 7.5 mg and 4 per day at different time.

  5. I felt a little sleepy on my second off that okay but I can’t in you to stay awake everything else is good just a little sleepy first time

  6. I’m curious to know. My friend takes hydrcodone prescribed. What happens if you took 5 hydrocodone 5/500 at once? She takes one every 4 hours but, she slipped up once and had three all in 5 hours accidently. She had a check up and is fine. But I’m curious.

  7. I’ve been addicted to hydro for years maybe 10 a day it’s the only way I can control my alcoholism scence Prince has passed the DR has cut my prescription and cut my klonophin ( I was on 2mg) off I have panic attacks can’t sleep and had severe klonophin withdrawal. they did the same thing when M.J passed. Good luck to us all.

  8. I been on on loritabs 7.5 for a year had two operations on my left leg twices now I haven’t took a pill for three day I been throwing up can’t sleep pain in my stomach I feel as if I’m dieding no energy

  9. Hi I wrote a message last year,well..unfortunately My husband is still addicted to pain pills,I don’t need help,but maybe this can help someone,my husband takes so many in a day that he has gotten a imune to them,he takes them whenever he doesnt feel good,whether it is a headache, body aches,super tired,dipressed,anything,since Tylenol or anything like that won’t work on him narcotics are probly the only thing he will take,it is a very sad thing,have tried getting help but never went tru it because they couldn’t help with much but said they will give ibuprofen for the pain withdrawls,any of those over the counter medicines never works for him,and tried going cold turkey since he had no choice cause he runed out a lot of times,but felt like he was gonna die and it was the end of the world for him,not long before he gets some again,but the bad thing is that even with them,it doesn’t make things any better,like if he can’t get out of bed and has a huge migraine or body aches or anything wrong with him when he takes his pill the pain may go away but it’s like he gets lost in his own world sleeps a lot! And when he does get up its mostly to do something for himself workout watch a movie or play video games he hardly spends time with me or his kids 🙁 and that’s only because I have to yell at him and he feels guilty so he tries to make himself feel better by spending time with us,but even that is just for little while,then he goes away.. is not the same like I said he is always in bed Eighter sleeping or not feeling well or spends his time watching tv or playing video games and works when he can,he’s always feeling sick that he can’t keep a job or work and it’s not bcause he’s lazy trust me he’s worked all his life hes always been a good worker,but sadly yes he does really get sick ,dizzy his pressure goes up and get horrible anxiety and panic attacks and much more,I know its the pills to blame,I believe they did this to him he can’t live without them but they are also killing him:( that is his life I would say 80% percent of his life is away from his family,we have 5 kids and it’s so hard because it’s like I’m a single parent I want him around I want to have a happy life with him,I wanna live my life with my husband and kids like any normal family should, 🙁 he will never want to admit to doctors he’s addicted since he doesn’t ever want to stop taking them,they have become part of him and honestly I don’t think its possible for him to ever stop taking them or physiclly needing them,he can’t live without them literly he goes insane and sick to death,I have witnessed it,I have cried and watched my husband say ‘please! put a bullet tru my head!’ because he rather die then feel pain of withdrawls from not being able to have a pain pill to make him live for the day and make him get tru the day,I have given up trying to make him stop

  10. Well, hello there. I’m 47yrs old, I’ve been taking hydrocodone for 8 years now. 10/325’s. I get 120 pills every 28 days. I don’t understand how someone “takes too many” & dies! ?

  11. Hey guys. I’m a student athlete in college. I’m a freshman who plays basketball. The summer before the start of the season I tore my labrum in my shoulder and I also tore my meniscus in my knee. I got my meniscus surgically repaired but never did anything for the labrum, just PT and the RICE treatment. I was fine for a few games into the season, but than my pain in my knee and especially my shoulder became unbearable. It got so bad that I didn’t think I could play anymore. I had some hydros left from when they give me some after my surgery so I tried taking some and they helped so much. If I take 2 pills before I go to bed, my body feels basically numb and I’ll sleep very good. The next day I will be pain free and will be able to play and practice and workout all day with very little pain. My girlfriend started to get upset with me because she thought I was dependent on hydros so I tried stopping but the pain is just too much. If I don’t take a few pills about every other day, I can’t play because the pain is so severe. I just want to know if I can hurt myself doing this. I plan on stopping as soon as our season is over but I don’t want to harm myself while I’m taking them. Can I die from this?

    1. Hi, Adrienne. We are here to help you with an addiction problem, not to give you fatal dosage, which varies from person to person. I’d suggest you to reconsider what you are going to do, and take a time to think about your family, friends, and everyone who cares for you. Believe me you’re not alone! Also, we are here for you, if you need any help…

  12. Okay I got to a doc every two weeks for Hydro. My Doc takes blood each 3 months. His nurse for got to take a urine test that day so I ask If I could give her the urine to you know clean up her files. I take med, Lisinopril hctz 20/25 mg twice a day, take metoprolol tartrate 25mg, montelukast 10mg qd, ventafaxine 75mg twice a day, diphenoxylate/atropine table( no gall bladder), I take otc anit-diarrheal each day two in morning. I take hydo 10mg/325mg 4 or 5 a day. I take diazepam 5mg each day or prn.
    when nurse took urine, they all flipped out and just about ran me out of the office. They said I have hydo at a high amount, I took pcp, they said I have a lot of opiumoids in my system. I was sick sunday from some fish make me run to bathroom, so I took about 4 of the diphenoxylate over two hours to stop the running to the bathroom. it did not stop so I took the otc anti diarrheal too. so that was like 6 of them they are false positive for opiumoid. that same night, I took my hydro, and the diazepam. Next morning I took a diphenoxylate so I would not go to the bathroom in my pants at the doc office, I took my hydro, so over 24 hours, I took about 5 hydro, one diazepam, one diphenoxylate, my bp medicinces, my ventafixine, montrlukast, I think that was it. I was told it was took to the local hospital for testing. then I told that they sent it to atlandta ga to the CDC. And they gave me the run around all week. He left me without any help. They pharmacy said since I took so many diphenoxylate in one day it kick my system into a false positive testing. I have a million questions why and where did I get PCP?

    1. Hi, Me. That’s a huge amount of hydrocodone. In some case, it can lead to OD. I suggest you take dosage as prescribed.

    1. Hi Faith. You can seek help for your sister in law and find a treatment facility that will help her get off hydrocodone safely. With the right support and treatment program she can stay clean long-term. If you’d like to get informed about treatment options available, call our trusted treatment providers by dialing he helpline number displayed on our site, or search here:

    1. Hi Diane. He will need help to come off hydrocodone completely. You can ask his GP or prescribing doctor for a referral or call the helpline number displayed on our site to get in touch with our trusted treatment providers that will help you find the right program that fits your husbands needs best.

  13. So my 13 year old son was prescribed this for his cough I gave him 1 1/2 teaspoons and it made him hear and see mummies and monsters he thought that they were attacking him and screamed why me stop it all day is this normal.

    1. Hi Dawn. I suggest you report these side-effects to the doctor. How many mL is one teaspoon? The usual pediatric dose for children is in the range between 2.5 mL – 5 mL of syrup taken orally every 4 to 6 hours as needed.

  14. hi my husband has been taking lortab mix with somas about 4 or 5 times a day because of his lower back pain and he’s been takeing both At the same time mix pills for about 5 years now he’s always passing out outside and mumbling and tumbling every were he can’t even walk I have to literally drag him inside and the worst part he drink alcohol once in awhile mostly every day ones a day night mostly what is his behavior telling me about him are the pills hurting him slowly he mumbles and he passes out everywhere I don’t know what to do at this point he never listen to me he to stubborn he does whatever he wants without no one telling him what to do at this point I am lost

    1. Hi Frances. I’d suggest that maybe it’s time to call some professional medical help to help you and your husband out. He may need to attend a treatment clinic and then continue his recovery process with counseling and psychotherapy. You too can benefit some therapy sessions to help you cope with all the pressure and learn positive ways you can influence his recovery.

  15. I have been prescribed Hydrocodone 10/325 X 4 a day for 5 years now. Pain is my first symptom with my disease. I have 2 questions;
    1). Is there any Hydrocodone that is available with a lesser amount of Tylenol? I fear Liver damage.
    2). Besides overdose, how can I die from Hydrocodone?
    I also take Baclofen and Lyrica everyday. Overall pain is lessened about 50% with all these drugs. I’m wondering … Is it worth it?
    Thank you

  16. I took around 50 or more hydrocod/aceta 5-325 with around 25 ropinipole 1mg. I am 72years of age. I did’nt want to wake up in the morning, but I did & now I am wondering what I should do to get back on my feet without going to the hospital? I hav never attemped anything like before & will not again.

  17. Hi Carol Ann. I’m sorry for your loss. But, I believe it’s impossible, since death is declared when the heart and brain stop functioning. Without them the body cannot secrete important hormones needed to keep biological processes, including gastric, kidney and immune functions. Thus, metabolic functions aren’t possible.

  18. My sister’s autopsy revealed a toxic level of Hydrocodone. She died at 4PM but blood was not drawn until 9AM the next day. Does Hydrocodone continue to metabolize after death?

  19. Hi Mr. Anonymoose. It’s difficult to quit hydrocodone cold turkey. Why don’t you try slowly tapering off of the drug? By doing so, the withdrawal symptom’s severity will be lowered and the chances for success increased. Here are two links from related articles that can give you more information:

  20. I’m badly addicted to hydro. I don’t know what to do. I have a 1 year old and a great wife. They don’t know of my habit but it has to STOP. I can’t even get out of bed without them and I run a full time business. No judging would be nice. I have tried quitting CTurkey but failed. I want my life back.

  21. I have been taking one dose or another of hydrocodone for about 11 years. My current dosage is 10/325 3 x’s daily. Could this be the cause of my sleep apnea or my low oxygen levels while l sleep?

  22. Hello Lisette. Have you consulted with a licensed psychologist or psychiatrist about this issue? Your husband may require professional help in order to stop…and doctors can set up tapering plans that make sense. I’d suggest a medical consult ASAP.

  23. Hi my husband has been taking pain pills for alon time now maybe about 3 years on and off,he is addictive to it,but has slowed down on takin them,he usually takes a lot in one day,he has been having a lot of stomach aches,and also said he’s been having bloody noise,and been getting bad migraines that even with the pain pills they won’t go away,I am afraid that he will die from taking it,I know their is something wrong with his health but he also suffers from anxiety attacks (panic attacks) telling him that I think hes really sick will make him freak out an cause him a panic attack an they are no joke,it gets to a point where he thinks he’s gonna die he calls the ambulance,I don’t know what to do please help me I don’t want to loose him

  24. Hi John. Opioids like hydrocodone and oxycodone reduce motility by increasing smooth muscle tone in the stomach and duodenum. In the small intestine, digestion of food is delayed by decreases in propulsive contractions. Other opioid effects include contraction of biliary tract smooth muscle, spasm of the Sphincter of Oddi, increased ureteral and bladder sphincter tone, and a reduction in uterine tone. While this may explain the discomfort in your abdomen, it doesn’t really help you practically. Have your prescribing doctors noted these effects?

  25. I was given Hydrocodone 5/325 to take 2 pills three times a day, about three months ago. Well, I have been taking the prescribed dose and a half pill, and I sometimes take two or three half pills about an hour apart after taking the prescribed dose. I usually don’t take any more Hydrocodone for that day. I have been experiencing some pain and discomfort in the upper quadrant of my abdomen for some time, but it usually subsides when I lessen the doses. I have had blood and urine tests and x-rays several times. Each time, everything came out normal; no damage detected. I am currently still taking the medicine and doing the same as before. I would like to add here that I have been prescribed Oxycontin and Vicodin over the past several years; always the pain in the abdominal area.

  26. Hello Juan. Thanks for your question. I would certainly report this side effect to your prescribing doctor. Slowed breathing is a signal that hydrocodone may be too strong an opioid for your body and central nervous system. Or you may need to adjust dosage.

    Long term effects of opioids are unknown at the moment, although hydrocodone may affect the liver. Check in also with your doctor about where to look up studies on the long term effects of hydrocodone…and let us know how it goes!

  27. I was just curious if taking half a pill a day for my lower back issues will cause long term effects, and if so what are they. I do notice slow breathing even when I only take half a pill, is that dangerous?

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