How long does it take before methadone wears off? Generally, after a single oral dose effects can last from 6 to 8 hours, depending on patterns of use. More on duration of methadone effects here.
methadone drug testing
Methadone is a long acting opioid. Methadone stays in your system and can be detected 2-4 days after last dose. More on methadone testing, detection times, and signs of methadone addiction here.