Spice is a relatively new drug and there is still only a little that we know about the effects of long term use. Even with such limited scientific knowledge, we can say that Spice is a substance with gruesome consequences. More, here.
Tolerance to Spice manifests as the need to smoke more Spice to get high. What are some other signs of Spice tolerance? We explore here.
Dependence on Spice is characterised by withdrawal symptoms when you cut back. More physical and psychological symptoms of Spice dependence here.