Cocaine interferes with the activity of the neurotransmitter, dopamine. It acts upon a part of the brain called the ventral tegmental area (VTA). More here on the chemistry behind the cocaine high.
What are the systemic effects of cocaine on your body and mind? We explore in-depth here.
Dependence on cocaine is diagnosed during withdrawal; symptoms include intense drug cravings, mood disorders, extreme fatigue, and dysphoria (inability to experience pleasure). More on cocaine dependence here.
Tolerance to cocaine develops rapidly, especially with continual heavy use. More on how people develop tolerance to cocaine and whether or not you can lower cocaine tolerance here.
Yes, coke can very easily become addictive. We review how you get addicted to coke and how to avoid coke addiction here.